I am using Blender 2.79b on a Windows 10 system with two GTX 1080Ti cards and latest nVidia video drivers, 64 GB RAM. Usually it works perfectly, but sometimes it fails to start with the message "Your system does not use 3D hardware acceleration". In the DOS box, two other error messages appear:
When this happens, retrying never fixes it. Sometimes rebooting fixes it, but sometimes I have to uninstall and then reinstall Blender. So frustrating!