Please provide all the requested information, and particularly a .blend to reproduce the problem:
I cannot reproduce the problem using last 2.79.1 compilation in Windows 10 64 bits.
http://prntscr.com/gbkc18 Take a look on splash screen. Is it another version?
The same result with 2.79 RC2 (unable to reproduce):
You are right, it works after reopening the file. Try to draw the circle, then modify it in another frame and add the sequence interpolation between to strokes. You will see the bug.
Yes, I can reproduce it now.
Sure it's related to the recalc filling cache flag for new strokes.
Thank you, Antonio!