Operating system: Darwin-18.7.0-x86_64-i386-64bit 64 Bits
Graphics card: Intel(R) Iris(TM) Graphics 540 Intel Inc. 4.1 INTEL-12.10.12
Broken: version: 2.80 and 2.81 (sub 11), branch: master, commit date: 2019-09-16 21:02, hash: rB76650402f300
Short description of error
On MacOS when you try to open any .blend file from finder, when Blender is already running on a different desktop (workspace, also when it is running fullscreen), nothing happens (except for the menu bar saying blender until you click somewhere else). When opened from the same desktop space, the blend files open as expected.
Exact steps for others to reproduce the error
Have a Blender window open regular or fullscreen.
On a different desktop, from finder click a blend file to try to open it. Blender does not react to this.